麻省理工学院(Massachusetts Institute of Technology)

创立于1861年, 坐落于美国马萨诸塞州剑桥市(大波士顿地区),是世界著名私立研究型大学。 作为世界顶尖高校,麻省理工学院尤其以自然及工程学享誉世界,位列2015-16 年世界大学学术排名(ARWU)工程学世界第1、计算机科学第2,与斯坦福大 学、加州大学伯克利分校一同被称为工程科技界的学术领袖。截至2017年,著名马萨诸塞州理工师生、校友或研究人员包括了91位诺贝尔奖得主、52位国家科学奖章获奖者、45位罗德学者、38名麦克阿瑟奖得主、6名菲尔兹奖获奖者、25位图灵奖得主。此校同时具很强的创业文化,由其校友所创办的公司利润总值相当于全球第十一大经济体。

麻省理工学院-计算化学、物理及信息交叉

一、科研内容参考

 

1Computational Chemistry 计算化学方向:适合化学/物理专业学生

Keywords: water, statistical mechanics, molecular dynamics simulation

Candidates: Students who have a major in chemistry/physics.

Water is the matrix of life and plays important roles in many chemical processes. Although water has a sim- ple molecular structure known by us since high school, water is still shrouded in mystery. Inorganic salts dis- solve in water and form aqueous electrolyte solutions containing individual ions. Ions influence on many aspects of water including structure and dynamics. In this project, we will investigate the ion effect on water from a computational and theoretical perspective.

Skills gained from the project:

1. Understanding molecular dynamics simulation

2. Advanced statistical mechanics, for example, the Kirk wood-Buff theory

3. Programming skills
4. Organizing a research project

 

2Biophysics 生物物理方向:适合化学/物理/生物/计算机专业学生

Keywords: chromatin, polymer modeling

Candidates: Students who have a major in chemistry/physics/biology/computer science.

Eukaryotic genomes in the interphase are tightly packaged within cell nuclei, fold into compact 3D struc- tures, and form chromosome territories. The spatial organization of chromatin plays an essential role in vari- ous genome functions, including gene expression, DNA replication and cell mitosis. Recently, the experi- mental techniques based on high- throughput sequencing and imaging have provided profound structural in- sights for chromosome. In this project, we will dig into the experimental data and investigate how the chro- mosome folds.

Skills gained from the project:

1. Getting familiar with biology experiment seven without background

2. Programming skills
3. Inter disciplinary research

4. Organizing a research project

 

3Bioinformatics 生物信息学方向:适合化学/物理/生物/计算机专业学生

Keywords: DNA methylation, data analysis

Candidates: Students who have a major in chemistry/physics/biology/computer science.

DNA methylation, as the most abundant epigenetic modification in eukaryotic chromosomes, is thought to influence chromatin structure. DNA methylation has a close relationship with nucleosome positioning, and the binding of CCCTC-binding factor can be partly influenced by DNA methylation and thus changes chro- matin structure. Nevertheless, how DNA methylation relates to chromatin structure remains largely un- known. In this project, we will study the relation between DNA methylation and chromatin structure.

Skills gained from the project:

1. Getting familiar with biology experiments even without background

2. Programming skills
3. Inter disciplinary research

4. Organizing a research project

 

4Machine Learning 机器学习方向:适合化学/物理/生物/计算机专业学生

Keywords: Boltzmann machine, maximum entropy model, variational autoencoder Candidates: Students who have a major in chemistry/physics/biology/computer science.

Huge amounts of data have been generated in biology. Considering the high dimensionality and big noise, generally its hard to extract useful information from the data. Machine learning, including deep learning, has been shown to be powerful in understanding biology. In this project, we will employ advanced machine learning techniques to solve cutting-edge biology problems.

Skills gained from the project:

1. Getting familiar with biological experiment seven without biology background

2. Machine learning techniques
3. Programming skills
4. Interdisciplinary research
5. Organizing a research project

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