哈佛大学(Harvard University)

为一所本部坐落于马萨诸塞州剑桥市的私立研究型大学。其因历史、学术影响力、财富等因素而获评为世上最享负盛名的学府之一。 哈佛于1636年由当地的殖民地立法机关立案成立,迄今为全美历史最悠久的高等学府,并拥有北美最古老的校董委员会。 哈佛大学为全美最难入读的学府之一。学校的研究生课程较为多元化,而本科教育则主要集中在文理学范畴。哈佛拥有全美最古老的图书馆系统,这同时也是全球最具规模的私立及大学图书馆系统,馆藏量逾1600万册。 其为常春藤盟校成员之一。哈佛校友涵盖8名美国总统及多国领袖与政治要员;其亦培养了62名富豪企业家及335位罗德学者,人数均为全美最多;另也有150多名诺贝尔奖得主现在或曾经在哈佛学习或工作。

哈佛大学-生物医学科研「干细胞与再生生物学」

一、课题方向

光遗传学技术

扩张显微镜

CLARITY 脑成像研究

神经通路追踪技术

基因编辑技术

细胞特异性表达研究

 

二、导师背景

干细胞和再生生物学系的副教授

哈佛哈佛大学干细胞研究所

 

三、科研内容参考

The Cellular and Molecular Identity of the Stem Cell Niche

Feedback regulation by stem cell progeny
We have pioneered studies to identify stem cell progeny as important regulators of activity of parental stem cells (Hsu et al., Cell 2011, Hsu et al., Cell 2014). Currently, we are identifying specific signaling factors that govern this feedback regulation.

Identification of novel niche cell types and signals
With new tools that we established, we are systematically identifying novel cell types and secreted factors that govern stem cell quiescence, promote stem cell self-renewal, and instruct stem cell fate decisions.

Modification of stem cell behavior to enhance wound repair
More than 100 million people develop scars each year as a result of trauma, surgery, or burns. At least 6 million people suffer from chronic non-healing wounds (including diabetic foot ulcers and bedsores). We are applying what we have learned about how the niche regulates skin stem cells to develop novel wound healing strategies.

Function and Biology of Transit-Amplifying Cells

TACs of one tissue control changes in many neighboring tissues
How tissues of different lineage grow together in an organ is a fundamental question in developmental biology. We discovered that hair follicle TACs control growth of the hair follicle itself and production of neighboring dermal adipocytes, coupling activity of two lineages (Zhang et al, G&D 2016). Currently, we are defining TAC function in regulating other tissues in the skin.

TACs and chemotherapy-related side effects
The highly proliferative nature of TACs is what makes them, not slow-cycling stem cells, a primary target of cytotoxic chemotherapies. Thus, understanding TAC function may inform strategies to prevent chemotherapy-related damage to tissues and organs. By studying the biology of TACs, we have discovered the root causes for several chemotherapy-related side effects, including hair loss, delayed wound healing, and susceptibility to infections. We are working on the cellular and molecular mechanisms leading to these phenotypes.

How Systemic Changes Regulate Stem Cell Behavior

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